New research reveals how adverse experiences in early life may rewire gut-brain pathways, increasing long-term risk for disorders of gut-brain interaction.
A new paper published in Gastroenterology shows that early life stress can disrupt gut-brain development and increase the risk of disorders of gut-brain interaction.
Using a mouse model, researchers found that early stress increased gut sensitivity, sex-specific problems with intestinal movement, and led to lasting changes in the gut’s nervous system.
These findings were supported by data from two large pediatric cohorts, which showed that maternal mental health problems were linked to a higher risk of pediatric disorders of gut-brain interaction. The consistency between preclinical and human data underscores the lasting impact of early-life stress on gut-brain pathways.
Takeaway:
Together, the results indicate that early-life stress can alter gut nerve function and signaling, increasing the risk of disorders of gut-brain interaction, suggesting new approaches for prevention and treatment.
Meet a co-author
AGA is proud to recognize co-author Daniel Juarez. In 2024, the AGA Research Foundation selected Daniel for the AGA-Dr. Harvey Young Education & Development Foundation’s Young Guts Scholars Program. He credits AGA’s undergraduate research program with kick-starting his research career and connecting him with mentors and collaborators involved in work like this study.
